WHAT DOES CHECK IT OUT MEAN?

DNA ligases seal 5′-PO4 and 3′-OH polynucleotide ends by using a few nucleotidyl transfer actions involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal buildings of DNA ligases bound to nucleotide and nucleic ac